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A mucous membrane or mucosa is a membrane that lines various cavities in the body and covers the surface of internal organs. It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It is mostly of endodermal origin and is continuous with the skin at various body openings such as the eyes, ears, inside the nose, inside the mouth, lip, vagina, the. Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer. Mucositis can occur anywhere along the gastrointestinal (gi) tract, but oral mucositis refers to the particular inflammation and ulceration that occurs in the mouth. Regardless, if you suffer from this disorder it can be embarrassing and uncomfortable. This narrowing may result from a true anatomic stricture or a muscular and functional stenosis. In anatomic anal stenosis, the normal pliable anoderm, to a varying extent, is replaced with restrictive cicatrized tissue. Of rectal submucosal lesions, disease processes that give rise to both intramural and extramural lesions should be considered (1, 2) (table 1). Anorectal symptoms and complaints are common and may be caused by a wide spectrum of conditions. Although most conditions are benign and may be successfully treated by primary care practitioners. Anal fissures are very common, and initially appear as an acute tear in the mucosal lining of the anal canal below the dentate line. These drugs dampen immune system response and calm mucosal irritation. For severe, unresponsive disease a colostomy or removal of the colon may be necessary.